Two sample MR report
APP_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.2656804 | 0.1986206 | 0.2386334 |
| Weighted median | 7 | 0.0699702 | 0.0266292 | 0.0085995 |
| Inverse variance weighted | 7 | 0.0511276 | 0.0211680 | 0.0157211 |
| Simple mode | 7 | 0.0763557 | 0.0327114 | 0.0583029 |
| Weighted mode | 7 | 0.0745172 | 0.0372257 | 0.0922000 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.580838 | 5 | 0.4691409 |
| Inverse variance weighted | 7.149479 | 6 | 0.3072445 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.2384667 | 0.1487908 | 0.1699037 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.46e-05 | 0 | TRUE | 0.4136315 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
